The principle of fat loss is to burn more calories (energy) to achieve the purpose of reducing body weight, which is what we say in our daily life, "keep your mouth shut and keep your legs open". Keeping your mouth shut means "controlling energy intake" and keeping your legs open means "increasing energy expenditure". However, in the face of thousands of food, we resist the temptation is too difficult, drugs have side effects, exercise is difficult to adhere to long-term, even if finally a little bit of success, a return to the original lifestyle, the fat immediately rebound back, how to lose weight in a healthy way is a problem?

Body management is a lifelong must for us, and we can adopt a scientific approach to make ourselves healthy and permanently thin, for example, through the intake of NMN, to enhance the level of NAD+ to promote the decomposition of fat and sugar, and to increase the basal metabolism, so as to make weight loss twice as easy as with half the effort.


NMN Fat Loss Principle I: Activation of SIRT1

As we age, NAD+ levels in the body decline; and low NAD+ levels can make the enzymes in our bodies that rely on NAD+ to function negatively and unable to function properly. In this case, there is the Sirtuins family, also known as the longevity family of proteins, which are very important in the fight against aging. there are 1-7 Sirtuins in the human body, of which SIRT1 has been shown to have a significant impact on fat metabolism.

1. Excessive use of SIRT1 causes adipocytes to display lower levels of leptin and lipocalin.

When leptin content levels drop, the brain lacks an effective reminder to stop eating and eats more, while reducing its own energy expenditure;

Lipocalin is an insulin sensitising hormone that ameliorates insulin resistance and atherosclerosis, meaning that reduced lipocalin increases the risk of type II diabetes and atherosclerosis.

2. SIRT1 promotes adipocyte mitochondrial bioactivity and respiration, and mitochondria promote adipocyte consumption and increase basal metabolism.

3. SIRT1 reduction promotes lipid accumulation in cells.


NMN Fat Loss Principle II: Reducing Fat Cell Production

The research team's 2019 study, published in a Nature subissue, corroborates NMN's help in weight loss from a stem cell perspective. Mesenchymal stem cells (MSCs) have the potential for self-renewal and multidirectional differentiation into various mesenchymal tissues, such as bone, cartilage, adipose and bone marrow haematopoietic tissues. With age, MSCs have an imbalance in energy metabolism, which leads to a decrease in osteogenic differentiation and an increase in adipocyte differentiation. NMN supplementation activates SIRT1, a longevity protein family, which in turn promotes the generation of osteoblasts from mesenchymal stromal stem cells (MSCs) and reduces the growth of adipocytes.




NMN Fat Loss Principle III: Preventing Metabolic Abnormalities in High-Fat Diets

NMN also helps prevent metabolic abnormalities caused by a high-fat diet; 4-week-old mice were subjected to either a normal diet or a high-fat diet for 12 weeks and were found to weigh significantly more than the high-fat diet mice. Using a control, the researchers gave some of the high-fat diet mice intraperitoneal injections of NMN for 10 consecutive days and found that NMN reduced fat size in the high-fat diet mice.


NMN Fat Loss Principle IV: Increase Basal Metabolism

A dream of the "lying thin" world: a team of researchers at Washington University in St. Louis, USA, Professor Shinichiro Imai, found in 2016 that NMN helps to suppress age-related weight gain and enhance energy metabolism; mice on NMN had higher food intake but weighed less compared to the control group.

Enhance basal metabolism, promote fat cell consumption, but also through leptin to maintain the effect of fat loss, to prevent metabolic abnormalities of high-fat diets, with NMN, a good partner for fat loss, for your weight loss cause.