NMN shows great potential in the prevention and improvement of cardiovascular and cerebrovascular diseases through mechanisms such as improving endothelial function, restoring vascular elasticity, acting as an antioxidant, regulating blood glucose and lipids, protecting cardiomyocytes, and inhibiting platelet aggregation.


1. Benefits of NMN for Cardiovascular and Cerebrovascular Health

Improvement of Endothelial Function

NMN can enhance endothelial function by scavenging superoxide radicals within the blood vessels, helping to maintain normal vascular function and prevent thrombosis.

By increasing NAD+ levels, NMN activates endothelial nitric oxide synthase (eNOS), promoting the synthesis of nitric oxide. Nitric oxide relaxes vascular smooth muscle, increases the diameter of blood vessels, improves blood circulation, lowers blood pressure, and helps prevent hypertension-related damage to the cardiovascular and cerebrovascular systems.


Restoration of Vascular Elasticity and Prevention of Atherosclerosis

As we age, collagen in the blood vessels gradually decreases, leading to reduced vascular elasticity. NMN can promote the synthesis of collagen within the blood vessels, increasing vascular elasticity and enhancing blood circulation.

By inhibiting inflammatory responses and reducing oxidative stress, NMN helps lower the risk of atherosclerosis and protects the cardiovascular and cerebrovascular systems from harmful factors.


Antioxidant Effect

NMN has antioxidant properties, capable of scavenging free radicals in the body and reducing oxidative stress-induced damage to the cardiovascular and cerebrovascular systems.

It also enhances the activity of intracellular antioxidant enzymes, such as superoxide dismutase (SOD) and catalase (CAT), further boosting the cell's antioxidant defense capabilities.


2. Mechanisms by Which NMN Prevents and Improves Cardiovascular and Cerebrovascular Diseases

Regulation of Blood Glucose and Lipids

NMN can activate and repair longevity-associated protein genes, playing a role in regulating blood glucose and reducing insulin resistance.

By modulating the expression of genes related to lipid metabolism in liver cells, NMN can lower the levels of total cholesterol, triglycerides, and low-density lipoprotein cholesterol (LDL-C) in the blood, while increasing high-density lipoprotein cholesterol (HDL-C) levels. HDL-C, known as "good cholesterol," helps reduce the deposition of cholesterol in the blood vessel walls.


Protection of Cardiomyocytes

After entering cardiomyocytes, NMN can increase intracellular NAD+ levels, activate mitochondrial respiration, and enhance the production of adenosine triphosphate (ATP), providing sufficient energy for the cardiomyocytes.

By activating survival signaling pathways such as the PI3K/Akt pathway, NMN can inhibit the expression of apoptosis-related proteins in cardiomyocytes, reducing cell apoptosis.

Additionally, it promotes the proliferation and differentiation of cardiac stem cells, increasing the number of cardiomyocytes and aiding in the repair of damaged heart tissue.


Inhibition of Platelet Aggregation

Platelet aggregation is a key step in thrombosis formation. NMN can inhibit platelet activation and aggregation, reducing blood coagulability and lowering the likelihood of thrombosis.

It also improves the thromboresistant function of the endothelial cells, preventing the attachment and growth of thrombi within the blood vessels.


3. Prospects of NMN in Cardiovascular and Cerebrovascular Diseases

Adjunctive Therapy

For patients with existing cardiovascular and cerebrovascular diseases, NMN can serve as an adjunctive treatment. By improving endothelial function, restoring vascular elasticity, providing antioxidant effects, and protecting cardiomyocytes, NMN can help alleviate symptoms and slow disease progression.


Preventive Effects

Long-term use of NMN helps prevent the occurrence of cardiovascular and cerebrovascular diseases, playing an active role through the regulation of blood glucose, blood lipids, and protection of the cardiovascular system.

The dosage and administration of NMN should also be adjusted based on individual circumstances.